HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ethyl vinyl ether → 1-Ethoxyethyl ether
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ethyl vinyl ether | HCID 8023 | — |
| Edukt | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Edukt | 1,9,18-Tris(benzenesulfonyl)-3,7,12,16-tetramethyl-1,18-bis(2,6,6-trimethyl-1-cycl ohexen-1-yl)-3,7,11,15-octadecatetraene-2,17-diol | HCID 86637461 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | 1-Ethoxyethyl ether | HCID 10464631 | 240% |
Reaktionsschritte
To a stirred solution of the C40 diol compound (O) (0.12 g, 0.13 mmol) in CH2Cl2 (5 mL) at 0° C. were added ethyl vinyl ether (0.71 mL, 0.73 mmol) and pyridinium p-toluenesulfonate (10 mg, 0.05 mmol). The mixture was stirred at room temperature for 20 h. The mixture was then diluted with CH2Cl2 (20 mL), washed with saturated NaHCO3 (10 mL×3), dried over anhydrous K2CO3, filtered, and concentrated under reduced pressure. The crude product was purified by silica gel (deactivated by Et3N) column chromatography to give the bis(1-ethoxyethyl)ether (P-3) (0.13 g, 0.12 mmol) in 90% yield.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07928266B2 |
| Quelldatensatz | uspto-grants-2011_04 |
| ORD ID | ord-77ffbc215c414aad9702a399bbd1c47c |
| Quellennotiz | uspto-grants-2011_04 |