5-Methylthiophene-2-carboxylic acid → 1-(5-Phenyl-thieno[3,2-c]pyrazol-1-yl)-ethanone
Reaktionsgleichung
CO[C:3]([C:5]1[S:12][C:11]2[CH:10]=[N:9][N:8]([C:13](=[O:15])[CH3:14])[C:7]=2[CH:6]=1)=O.[CH3:16][C:17]1S[C:20](C(O)=O)=[CH:19][CH:18]=1>>[C:3]1([C:5]2[S:12][C:11]3[CH:10]=[N:9][N:8]([C:13](=[O:15])[CH3:14])[C:7]=3[CH:6]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1Komponenten
3
Versuchsvorschrift
1-(5-phenyl-thieno[3,2-c]pyrazol-1-yl)-ethanone [Intermediate (44), LC/MS: 243.1 (M+H), RT=3.45 minutes; 1H NMR (300 Mhz, CDCl3): δ 7.84 (s, 1H), 7.78 (s, 1H), 7.64 (m, 2H), 7.43-7.31 (m, 3H), 2.75 (s, 3H)] is prepared using procedures similar to those described hereinabove for Intermediate (25) substituting 2-phenyl-5-methyl-thiophene for 5-methylthiophene-2-carboxylic acid in step 1.
Quellen und Nachweise
- ORD-Eintrag
- ord-0d8f2615a58a427ba20b8b65288f8103
- Quelldatensatz
- uspto-grants-2011_04
- DOI