Hydrochloric Acid → 4-(2-Hydroxyethoxy)-3-(trifluoromethyl)phenylboronic acid

HRID 2079536Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2079536
O1CCCCC1[O:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([B:17]([OH:19])[OH:18])=[CH:13][C:12]=1[C:20]([F:23])([F:22])[F:21].Cl>>[OH:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([B:17]([OH:18])[OH:19])=[CH:13][C:12]=1[C:20]([F:23])([F:21])[F:22]

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 576575904-(2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy)-3-(trifluoromethyl)phenylboronic acid

Produkt 1

HCID 576575404-(2-Hydroxyethoxy)-3-(trifluoromethyl)phenylboronic acid

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

4-(2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy)-3-(trifluoromethyl)phenylboronic acid (8 g) was added to hydrochloric acid (1M in MeOH) and the mixture was heated at 60° C. for 60 minutes. Solvent and HCl was then removed under reduced pressure and residue (5.52 g) was used for next step without further purification.

Aufarbeitung

  1. customSolvent and HCl was then removed under reduced pressure and residue (5.52 g)
  2. customwas used for next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-a8241856aa37480e9e8d34994f10f924
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07932251B2

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