Chloroacetyl chloride → HCID 178454048, Verbindung

HRID 2079602Notizen

Reaktionsgleichung

[NH2:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])[CH2:4][CH2:3]1.[Cl:16][CH2:17][C:18](Cl)=[O:19]>>[Cl:16][CH2:17][C:18]([NH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:15])[O:10][C:11]([CH3:12])([CH3:14])[CH3:13])[CH2:4][CH2:3]1)=[O:19]

Komponenten

Edukt 2

HCID 6577Chloroacetyl chloride

HCID 178419079HCID 178419079, Verbindung

Produkt 1

HCID 178454048HCID 178454048, VerbindungAusbeute 89 %

Versuchsvorschrift

The title compound 604 mg (89%) was obtained in a manner similar to the Manufacturing Example 3 by use of tert-butyl trans-4-aminocyclohexylcarbamate and chloroacetyl chloride, instead of the compound obtained in the Manufacturing Example 2 and acetyl chloride, respectively.

Quellen und Nachweise

ORD-Eintrag: ord-84dda81095a74644b02bb2877c1702b4
Quelldatensatz: uspto-grants-2011_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07932250B2

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