Sulfanilamide → 4-[[8-Bromo-6-(trifluoromethyl)-2-quinazolinyl]amino]benzenesulfonamide

HRID 2079629Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2079629
[Br:1][C:2]1[CH:3]=[C:4]([C:13]([F:16])([F:15])[F:14])[CH:5]=[C:6]2[C:11]=1[N:10]=[C:9](Cl)[N:8]=[CH:7]2.[S:17]([NH2:27])(=[O:26])([C:19]1[CH:24]=[CH:23][C:22]([NH2:25])=[CH:21][CH:20]=1)=[O:18]>CC(O)C>[Br:1][C:2]1[CH:3]=[C:4]([C:13]([F:16])([F:15])[F:14])[CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([NH:25][C:22]1[CH:23]=[CH:24][C:19]([S:17]([NH2:27])(=[O:18])=[O:26])=[CH:20][CH:21]=1)[N:8]=[CH:7]2

Komponenten

4

Edukt 2

HCID 5333SulfanilamideHCID 59199251HCID 59199251, Verbindung

Produkt 1

HCID 250160044-[[8-Bromo-6-(trifluoromethyl)-2-quinazolinyl]amino]benzenesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

To a 0.30 M solution of 8-bromo-2-chloro-6-(trifluoromethyl)quinazoline in 2-propanol was added sulfanilamide (1.0 eq). The reaction was stirred at 110° C. for 14 h. The hydrochloride was collected by vacuum filtration and then stirred in aqueous sodium bicarbonate. The solid was collected by vacuum filtration and rinsed with water. The light yellow solid was dried in a desiccator to give 343 mg of the desired product. ES/MS m/z 447, 449 (MH+).

Aufarbeitung

  1. filtrationThe hydrochloride was collected by vacuum filtration
  2. stirringstirred in aqueous sodium bicarbonate
  3. filtrationThe solid was collected by vacuum filtration
  4. washrinsed with water
  5. customThe light yellow solid was dried in a desiccator

Quellen und Nachweise

ORD-Eintrag
ord-0ded3928daca4d30a4e71ee1571a8a08
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07932262B2

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