Benzenamine, 4-(4-morpholinyl)- → 6-Bromo-7-methoxy-N-(4-morpholinophenyl)quinazolin-2-amine

HRID 2079647Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2079647
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[N:8]=[C:7](Cl)[N:6]=[CH:5]2.[O:15]1[CH2:20][CH2:19][N:18]([C:21]2[CH:27]=[CH:26][C:24]([NH2:25])=[CH:23][CH:22]=2)[CH2:17][CH2:16]1>C(O)(C)C>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[N:8]=[C:7]([NH:25][C:24]1[CH:23]=[CH:22][C:21]([N:18]3[CH2:19][CH2:20][O:15][CH2:16][CH2:17]3)=[CH:27][CH:26]=1)[N:6]=[CH:5]2

Komponenten

4

Edukt 2

HCID 75655Benzenamine, 4-(4-morpholinyl)-HCID 591992766-Bromo-2-chloro-7-methoxyquinazoline

Produkt 1

HCID 671026766-Bromo-7-methoxy-N-(4-morpholinophenyl)quinazolin-2-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

To a 0.12M suspension of 6-bromo-2-chloro-7-methoxyquinazoline (1.0 eq) in isopropanol was added 4-morpholinoaniline (1.0 eq). The reaction mixture was heated to 120° C. in an oil bath for 5 h. LCMS showed that reaction was complete under the condition. The reaction mixture was allowed to cool to room temperature and was filtered. The filter cake was rinsed with ethyl acetate and allowed air dry. Desired product was a brown solid as HCl salt. ES/MS m/z 415/417 (MH+).

Aufarbeitung

  1. customLCMS showed that reaction
  2. temperatureto cool to room temperature
  3. filtrationwas filtered
  4. washThe filter cake was rinsed with ethyl acetate
  5. customdry

Quellen und Nachweise

ORD-Eintrag
ord-05b2520886d443b78be622e7e1981454
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07932262B2

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