5-Benzylfuran-2-carbaldehyde → 5-(Phenylmethyl)-2-furanmethanamine
Reaktionsgleichung
[CH2:1]([C:8]1[O:12][C:11]([CH:13]=O)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:15].CO>[Ni]>[CH2:1]([C:8]1[O:12][C:11]([CH2:13][NH2:15])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
7N Ammonia/methanol(40 mL) and Raney nickel(3 g) were added to 5-benzyl-furan-2-carbaldehyde described in Preparation Example 39 (2.5 g, 13 mmol), and the solution was stirred for 22 hours under hydrogen atmosphere at room temperature. After removing the catalyst by filtering through Celite pad, the solvent was evaporated in vacuo and C-(5-benzyl-furan-2-yl)methylamine (1.6 g, 8.6 mmol, 65.8%) was obtained.
Aufarbeitung
- customAfter removing the catalyst
- filtrationby filtering through Celite pad
- customthe solvent was evaporated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-fa9049e0f9524da9bf4ee48ab4ee6885
- Quelldatensatz
- uspto-grants-2011_04
- Patentnummer
- US07932272B2
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