2-[2-(4-Dipropylaminobutyl)-1-methoxymethoxy-indan-5-ylmethyl]-isoindole-1,3-dione → 2-[2-(4-dipropylamino-butyl)-3H-inden-5-ylmethyl]-isoindol

HRID 2080739Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2080739
[CH2:1]([N:4]([CH2:34][CH2:35][CH3:36])[CH2:5][CH2:6][CH2:7][CH2:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([CH2:18][N:19]3[C:27](=O)[C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[C:20]3=O)[CH:15]=2)[CH:10]1OCOC)[CH2:2][CH3:3]>O1CCOCC1>[CH2:34]([N:4]([CH2:1][CH2:2][CH3:3])[CH2:5][CH2:6][CH2:7][CH2:8][C:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([CH2:18][N:19]3[CH:27]=[C:26]4[C:21]([CH:22]=[CH:23][CH:24]=[CH:25]4)=[CH:20]3)[CH:15]=2)[CH:10]=1)[CH2:35][CH3:36]

Komponenten

3

Edukt 1

HCID 231555482-[2-(4-Dipropylaminobutyl)-1-methoxymethoxy-indan-5-ylmethyl]-isoindole-1,3-dione

Produkt 1

HCID 866149102-[2-(4-dipropylamino-butyl)-3H-inden-5-ylmethyl]-isoindolAusbeute 107,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

The compound (113.0 mg) obtained in Example 11-11 was dissolved in dioxane (2.2 ml) and the whole was stirred at room temperature for 24 hours. The reaction solution was concentrated under reduced pressure. The residue was dissolved in chloroform and washed with a saturated aqueous sodium hydrogen carbonate solution and then with a saturated saline solution. The resultant was dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified through silica gel column chromatography (chloroform/methanol), thereby obtaining the subject compound (98.8 mg) as a yellow oily substance.

Aufarbeitung

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. dissolutionThe residue was dissolved in chloroform
  3. washwashed with a saturated aqueous sodium hydrogen carbonate solution
  4. dry with materialThe resultant was dried with anhydrous sodium sulfate
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was purified through silica gel column chromatography (chloroform/methanol)

Quellen und Nachweise

ORD-Eintrag
ord-f679ddba13f148f0859a4e35168388f2
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07932281B2

Notizen zur Reaktion

Wird geladen…