Sodium Hydroxide → 4-[(Dipropylamino)methyl]benzoic acid

HRID 2080793

Reaktionsgleichung

Reaktionsgleichung von HRID 2080793
C[O:2][C:3](=[O:18])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][N:11]([CH2:15][CH2:16][CH3:17])[CH2:12][CH2:13][CH3:14])=[CH:6][CH:5]=1.[OH-].[Na+]>CO>[CH2:12]([N:11]([CH2:10][C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:18])=[O:2])=[CH:5][CH:6]=1)[CH2:15][CH2:16][CH3:17])[CH2:13][CH3:14]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 23079192Methyl 4-dipropylaminomethylbenzoate

Produkt 1

HCID 167713874-[(Dipropylamino)methyl]benzoic acidAusbeute 98,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

The compound (883 mg) obtained in Example 29-2 was dissolved in methanol (18 ml) and added with a 1 mol/l sodium hydroxide aqueous solution (9.0 ml) and the whole was stirred overnight at room temperature. After completion of the reaction, the solvent was distilled off under reduced pressure. The residue was dissolved in 1 mol/l hydrochloric acid, subjected to extraction with chloroform, and dried with anhydrous sodium sulfate. After filtration, the solvent was distilled off and the residue was dried under vacuum, thereby obtaining the subject compound (820 mg) as a white solid.

Aufarbeitung

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off under reduced pressure
  3. dissolutionThe residue was dissolved in 1 mol/l hydrochloric acid
  4. extractionsubjected to extraction with chloroform
  5. dry with materialdried with anhydrous sodium sulfate
  6. filtrationAfter filtration
  7. distillationthe solvent was distilled off
  8. customthe residue was dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-4beb7815a0ad4c46a35bd951ea0a5971
Quelldatensatz
uspto-grants-2011_04
Patentnummer
US07932281B2

Verknüpfte Notizen

Wird geladen…