N-(1-benzylpiperid-4-yl)-N-methylpropionamide → N-Methyl-N-(piperidin-4-yl)propionamide

HRID 2082345Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2082345
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:19])[C:15](=[O:18])[CH2:16][CH3:17])[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[OH-].[Pd+2].[OH-]>[NH:8]1[CH2:13][CH2:12][CH:11]([N:14]([CH3:19])[C:15](=[O:18])[CH2:16][CH3:17])[CH2:10][CH2:9]1

Komponenten

4

Edukt 1

HCID 19761195N-(1-benzylpiperid-4-yl)-N-methylpropionamide

Produkt 1

HCID 19761222N-Methyl-N-(piperidin-4-yl)propionamideAusbeute 60 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

31 g of the amine obtained in Stage B are hydrogenated in 350 ml of ethanol with 1 g of palladium hydroxide at atmospheric pressure and room temperature. The mixture is filtered and evaporated to yield the desired product in the form of an oil.

Aufarbeitung

  1. filtrationThe mixture is filtered
  2. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-0295d3c8d845438e84752f73a7d8dbc2
Quelldatensatz
uspto-grants-1993_02
Patentnummer
US05189045

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