Benzyl Chloride → HCID 2845263, Verbindung

HRID 2082356Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2082356
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([NH:10][CH3:11])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[CH2:12](Cl)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([NH:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 7503Benzyl ChlorideHCID 10340Sodium CarbonateHCID 197612651-[4-(Methylamino)piperidin-1-yl]ethan-1-one

Produkt 1

HCID 2845263HCID 2845263, VerbindungAusbeute 65 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture containing 0.5 mol of the compound obtained in Stage A of Example 19, 0.5 M benzyl chloride and 1 M sodium carbonate in 650 ml of ethanol is refluxed for one night. The precipitate formed is filtered off, the solvent is evaporated, the evaporation residue is taken up in 1N hydrochloric acid and extracted with diethyl ether, and the ethereal extract is rendered basic with sodium hydroxide solution and extracted with ethyl acetate to obtain the desired compound.

Aufarbeitung

  1. temperatureis refluxed for one night
  2. customThe precipitate formed
  3. filtrationis filtered off
  4. customthe solvent is evaporated
  5. extractionextracted with diethyl ether
  6. extractionthe ethereal extract
  7. extractionextracted with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-dc67c0fc84074265b368bcbdce43d6ea
Quelldatensatz
uspto-grants-1993_02
Patentnummer
US05189045

Notizen zur Reaktion

Wird geladen…