Benzene → 2-[1-beta-Chloroethyl-3-(5-bromothiazol-2-yl)ureido]acetaldehyde

HRID 2083620Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2083620
[Br:1][C:2]1[S:6][C:5]([N:7]=[C:8]=[O:9])=[N:4][CH:3]=1.C1C=CC=CC=1.[Cl:16][CH2:17][CH2:18][NH:19][CH2:20][CH:21]=[O:22]>C(O)C.O>[Cl:16][CH2:17][CH2:18][N:19]([CH2:20][CH:21]=[O:22])[C:8]([NH:7][C:5]1[S:6][C:2]([Br:1])=[CH:3][N:4]=1)=[O:9]

Komponenten

5

Edukt 3

HCID 241BenzeneHCID 230622645-Bromothiazol-2-yl IsocyanateHCID 543320492-beta-Chloroethylaminoacetaldehyde

Produkt 1

HCID 541852552-[1-beta-Chloroethyl-3-(5-bromothiazol-2-yl)ureido]acetaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 19096565Water ethanolLösungsmittel

Versuchsvorschrift

5-Bromothiazol-2-yl isocyanate dimer (17.0 grams), benzene (70 ml) and the dimethyl acetal of 2-β-chloroethylaminoacetaldehyde (13.5 grams) are charged into a glass reaction vessel equipped with a mechanical stirrer and thermometer. The reaction mixture is then stirred at room temperature for a period of about one hour. After this time the reaction mixture is filtered, and the filtrate is stripped of solvent under reduced pressure, leaving an oil. This oil is dissolved in an ethanol-water mixture, and the solution is filtered. The filtrate is then stripped of solvents under vacuum to yield the desired product the dimethyl acetal of 2-[1-β-chloroethyl-3-(5-bromothiazol-2-yl)ureido]acetaldehyde.

Aufarbeitung

  1. customequipped with a mechanical stirrer
  2. filtrationAfter this time the reaction mixture is filtered
  3. customleaving an oil
  4. filtrationthe solution is filtered

Quellen und Nachweise

ORD-Eintrag
ord-84f07e699b154ed68faa9392adbdb45b
Quelldatensatz
uspto-grants-1978_04
Patentnummer
US04086240

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