HCID 178479460, Verbindung → HCID 178479458, Verbindung

HRID 2083832Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2083832
[ClH:1].C(OC([NH:12][C@H:13]([C:21]([N:23]1[CH2:34][CH2:33][CH2:32][C@H:24]1[C:25]([NH:27][CH2:28][C:29]([NH2:31])=[O:30])=[O:26])=[O:22])[CH2:14][CH2:15][CH2:16][NH:17][C:18](=[NH:20])[NH2:19])=O)C1C=CC=CC=1>CO>[ClH:1].[NH2:12][C@H:13]([C:21]([N:23]1[CH2:34][CH2:33][CH2:32][C@H:24]1[C:25]([NH:27][CH2:28][C:29]([NH2:31])=[O:30])=[O:26])=[O:22])[CH2:14][CH2:15][CH2:16][NH:17][C:18](=[NH:19])[NH2:20]

Komponenten

3

Edukt 1

HCID 178479460HCID 178479460, Verbindung

Produkt 1

HCID 178479458HCID 178479458, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Nα -Benzyloxycarbonyl-L-arginyl-L-prolyl-glycinamide hydrochloride, (Example 1, part m) 1.2 g., is dissolved in 60 ml. of absolute methanol, treated with 380 mg. of 10% palladium-on-carbon and the flask flushed with nitrogen, then with hydrogen and the reduction carried out for 40 minutes. Completion of the reaction is determined by thin layer chromatography. The mixture is filtered to separate the catalyst and the filtrate is evaporated and dried under reduced pressure to yield L-arginyl-L-prolyl-glycinamide hydrochloride.

Aufarbeitung

  1. dissolution, is dissolved in 60 ml
  2. customof 10% palladium-on-carbon and the flask flushed with nitrogen
  3. filtrationThe mixture is filtered
  4. customto separate the catalyst
  5. customthe filtrate is evaporated
  6. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-80f43f592b9f42b69472853689d5419c
Quelldatensatz
uspto-grants-1978_04
Patentnummer
US04086219

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