3-Amino-p-cresol → 4-(5-Hydroxy-2-methylanilino)-2-(2-pyridinyl)-6-trifluoromethylpyrimidine

HRID 2084230

Reaktionsgleichung

Reaktionsgleichung von HRID 2084230
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[N:3]=1.[OH:18][C:19]1[CH:20]=[CH:21][C:22]([CH3:26])=[C:23]([CH:25]=1)[NH2:24]>>[OH:18][C:19]1[CH:20]=[CH:21][C:22]([CH3:26])=[C:23]([CH:25]=1)[NH:24][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[N:3]=1

Komponenten

3

Edukt 2

HCID 178203-Amino-p-cresolHCID 113115004-Chloro-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine

Produkt 1

HCID 227323984-(5-Hydroxy-2-methylanilino)-2-(2-pyridinyl)-6-trifluoromethylpyrimidine

Versuchsvorschrift

The title compound was prepared from 4-chloro-2-(2-pyridinyl)-6-trifluoromethylpyrimidine (40 mg, 0.154 mmol) and 5-hydroxy-2-methylaniline (28 mg, 0.231 mmol) similar to example 185 and was isolated as a pale solid (40 mg, 75%). 1H NMR (CDCl3): 9.73 (m, 1H), 8.44-8.41 (m, 1H), 7.81-7.75 (m, 1H), 7.46 (s, 1H), 7.34-7.28 (m, 2H), 7.23 (t, J=8.1 Hz, 1H), 7.09-7.06 (m, 1H), 7.00-6.97 (m, 1H), 6.55 (d, J=0.6 Hz, 1H), 2.44 (s, 3H), 2.43 (d, J=0.6, 3H).

Quellen und Nachweise

ORD-Eintrag
ord-49fe2a646604430087ca60f372055454
Quelldatensatz
uspto-grants-2004_04
Patentnummer
US06716851B2

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