1,3-Propanediol → 4-(1,3,2-Dioxaborinan-2-yl)benzoic acid

HRID 2085743Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2085743
[OH:1][B:2]([OH:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1.[CH2:13](O)[CH2:14][CH2:15]O>C1(C)C=CC=CC=1>[O:1]1[CH2:15][CH2:14][CH2:13][O:12][B:2]1[C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1

Komponenten

4

Edukt 2

HCID 104421,3-PropanediolHCID 3121834-Carboxyphenylboronic Acid

Produkt 1

HCID 145278654-(1,3,2-Dioxaborinan-2-yl)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A mixture of 4-(dihydroxyboryl)benzoic acid (30.00 g, 181 mmol) and 1,3-propanediol (15.20 g, 200 mmol) in toluene (750 mL) at 140° C. was stirred for 6 hours while collecting the water removed by azeotrope formation. The mixture was concentrated to provide the desired product.

Aufarbeitung

  1. customwhile collecting the water
  2. customremoved by azeotrope formation
  3. concentrationThe mixture was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-1c9f953facd94e219498da73566bf0e1
Quelldatensatz
uspto-grants-2004_04
Patentnummer
US06720338B2

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