Hydrochloric Acid → 4-(6-Chloronaphthalene-2-sulfonyl)-1-[methyl(4-piperidinyl)amino]-2-piperazinone hydrochloride

HRID 2086243Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2086243
C(OC(N1CCCCC1[CH2:14][NH:15][N:16]1[CH2:21][CH2:20][N:19]([S:22]([C:25]2[CH:34]=[CH:33][C:32]3[C:27](=[CH:28][CH:29]=[C:30]([Cl:35])[CH:31]=3)[CH:26]=2)(=[O:24])=[O:23])[CH2:18][C:17]1=[O:36])=O)(C)(C)C.Cl.C(O[CH2:42][CH3:43])(=O)C>CO>[ClH:35].[Cl:35][C:30]1[CH:31]=[C:32]2[C:27](=[CH:28][CH:29]=1)[CH:26]=[C:25]([S:22]([N:19]1[CH2:20][CH2:21][N:16]([N:15]([CH3:14])[CH:43]3[CH2:42][CH2:21][NH:16][CH2:17][CH2:18]3)[C:17](=[O:36])[CH2:18]1)(=[O:24])=[O:23])[CH:34]=[CH:33]2

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 8857Ethyl Acetate2×HCID 695455571-{[1-(Tert-butoxycarbonyl)piperidinyl]methylamino}-4-(6-chloronaphthalene-2-sulfonyl)-2-piperazinone

Produkt 1

HCID 227272334-(6-Chloronaphthalene-2-sulfonyl)-1-[methyl(4-piperidinyl)amino]-2-piperazinone hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A suspension of 1-{[1-(tert-butoxycarbonyl)piperidinyl]methylamino}-4-(6-chloronaphthalene-2-sulfonyl)-2-piperazinone (10.42 g) in methanol (40 ml) was combined with a 4N solution of hydrochloric acid in ethyl acetate (20 ml) and stirred at room temperature for 5 hours. The reaction mixture was combined with ethyl acetate (50 ml) and the crystals precipitated were collected by filtration, dried to obtain the title compound (9.21 g) as colorless crystals.

Aufarbeitung

  1. customthe crystals precipitated
  2. filtrationwere collected by filtration
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-0884c1b9927e412dbdeffe76aca42517
Quelldatensatz
uspto-grants-2004_04
Patentnummer
US06723722B1

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