Thionyl Chloride → 3-Dichloromethylthio-7-fluoro-1-methyl-4-quinolone

HRID 2086911

Reaktionsgleichung

Reaktionsgleichung von HRID 2086911
S(Cl)([Cl:3])=O.[Cl:5][CH2:6][S:7]([C:9]1[C:18](=[O:19])[C:17]2[C:12](=[CH:13][C:14]([F:20])=[CH:15][CH:16]=2)[N:11]([CH3:21])[CH:10]=1)=O>N1C=CC=CC=1>[Cl:5][CH:6]([Cl:3])[S:7][C:9]1[C:18](=[O:19])[C:17]2[C:12](=[CH:13][C:14]([F:20])=[CH:15][CH:16]=2)[N:11]([CH3:21])[CH:10]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 104685473-Chloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone

Produkt 1

HCID 113237793-Dichloromethylthio-7-fluoro-1-methyl-4-quinolone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

To an efficiently stirred and gently cooled 4.2 ml mixture of thionyl chloride (“SOCl2”) and 1.05 ml of pyridine (“Py”) at −3° C. was added 1.015 g (3.708 mmol) of 3-chloromethylsulfinyl-7-fluoro-1-methyl-4-quinolone (monochloroflosequinan)(Compound 1 of FIG. 1). This addition was made in multiple alloquots over a period of approximately 1 min. During this addition, cooling was applied to keep the temperature in the range 0-5° C.

Aufarbeitung

  1. additionThis addition
  2. additionDuring this addition
  3. temperaturecooling
  4. customin the range 0-5° C.

Quellen und Nachweise

ORD-Eintrag
ord-273d39b67d384f8d85969decde7520cd
Quelldatensatz
uspto-grants-2004_04
Patentnummer
US06727262B2

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