Hydrochloric Acid → (R)-Pramipexole (dihydrochloride);R-(+)-Pramipexole (dihydrochloride);KNS-760704 (dihydrochloride)

HRID 2087083

Reaktionsgleichung

Reaktionsgleichung von HRID 2087083
[NH2:1][C:2]1[S:3][C:4]2[CH2:10][CH:9]([NH:11][CH2:12][CH2:13][CH3:14])[CH2:8][CH2:7][C:5]=2[N:6]=1.[ClH:15]>CO>[ClH:15].[NH2:1][C:2]1[S:3][C:4]2[CH2:10][CH:9]([NH:11][CH2:12][CH2:13][CH3:14])[CH2:8][CH2:7][C:5]=2[N:6]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 48854,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine

Produkt 1

HCID 11615735(R)-Pramipexole (dihydrochloride);R-(+)-Pramipexole (dihydrochloride);KNS-760704 (dihydrochloride)

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

4,2 g of (±)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole was dissolved in 15 mL of hot methanol and 1.65 mL of 36% hydrochloric acid was added. The obtained suspension was stirred, cooled and precipitated solid was filtered off. The cake was washed with cold methanol and air-dried to give 4.2 g of product with m.p. 273-282° C.

Aufarbeitung

  1. temperaturecooled
  2. customprecipitated solid
  3. filtrationwas filtered off
  4. washThe cake was washed with cold methanol
  5. customair-dried

Quellen und Nachweise

ORD-Eintrag
ord-47794402c36e46d48a85e147dce7bc35
Quelldatensatz
uspto-grants-2004_04
Patentnummer
US06727367B2

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