4-Bromophenacyl bromide → N-[4-(4-Bromo-phenyl)-1H-imidazol-2-yl]-acetamide

HRID 20885

Reaktionsgleichung

Reaktionsgleichung von HRID 20885
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1)=O.[C:12]([NH:15][C:16]([NH2:18])=[NH:17])(=[O:14])[CH3:13]>CN(C=O)C>[Br:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2[NH:18][C:16]([NH:15][C:12](=[O:14])[CH3:13])=[N:17][CH:2]=2)=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 74544-Bromophenacyl bromideHCID 178475102HCID 178475102, Verbindung

Produkt 1

HCID 10468856N-[4-(4-Bromo-phenyl)-1H-imidazol-2-yl]-acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 2-bromo-1-(4-bromophenyl)ethanone (2.00 g, 7.20 mmol) and acetylguanidine (2.18 g, 21.6 mmol) in DMF (40 mL) was stirred at rt for 48 h. The solution was concentrated to dryness in vacuo and the resulting brown solid was of sufficient purity for use in the next step. LCMS: Anal. Calcd. for C11H10BrN3O: 279, 281; found: 280, 282 (M+H)+.

Aufarbeitung

  1. concentrationThe solution was concentrated to dryness in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-9095334553934822abb0be22ce7699c7
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07745636B2

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