(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine → 4-(piperazin-1-yl)-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-2-amine

HRID 2088719Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2088719
CC1C=CC(S(O[C:12]2[C:13]3[CH2:23][CH2:22][CH2:21][CH2:20][C:19](C)(C)[C:14]=3[N:15]=[C:16]([NH2:18])[N:17]=2)(=O)=O)=CC=1.[NH:26]1[CH2:30]C[C@@H:28]([NH:31][C:32](=O)OC(C)(C)C)[CH2:27]1>>[N:26]1([C:12]2[C:13]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][C:14]=3[N:15]=[C:16]([NH2:18])[N:17]=2)[CH2:27][CH2:28][NH:31][CH2:32][CH2:30]1

Komponenten

3

Edukt 2

HCID 1514397(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidineHCID 866348802-amino-9,9-dimethyl-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-4-yl 4-methylbenzenesulfonate

Produkt 1

HCID 444668764-(piperazin-1-yl)-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-2-amine

Versuchsvorschrift

The title compound was prepared according to the procedure of Example 1E, substituting the product from Example 13C for the product of Example 1D and substituting piperazine for (R)-tert-butyl pyrrolidin-3-ylcarbamate. 1H NMR (300 MHz, CD3OD) δ 3.38 (m, 4H), 3.21 (, 4H), 2.74 (m, 2H), 2.62 (m, 2H), 1.86 (m, 2H), 1.57-1.71 (m, 4H). MS (DCI+) m/z 248 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-e9ab965c010e4a63bce4160fd8eb07a5
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08436005B2

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