2-Methyl-1,2,3,4-tetrahydroisoquinolin-7-amine → HCID 178480072, Verbindung

HRID 2088753

Reaktionsgleichung

Reaktionsgleichung von HRID 2088753
[CH3:1][N:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][C:6]([NH2:12])=[CH:7][CH:8]=2)[CH2:3]1.Cl[C:14]1[N:19]=[C:18]2[NH:20][C:21](=[O:34])[N:22]([C:25]3[C:30]([Cl:31])=[CH:29][C:28]([F:32])=[CH:27][C:26]=3[Cl:33])[C:23](=[NH:24])[C:17]2=[CH:16][N:15]=1.ClC1N=C2NC(=O)N(C3C(Cl)=CC=CC=3Cl)C(=N)C2=CN=1>>[Cl:31][C:30]1[CH:29]=[C:28]([F:32])[CH:27]=[C:26]([Cl:33])[C:25]=1[N:22]1[C:23](=[NH:24])[C:17]2[C:18](=[N:19][C:14]([NH:12][C:6]3[CH:5]=[C:4]4[C:9]([CH2:10][CH2:11][N:2]([CH3:1])[CH2:3]4)=[CH:8][CH:7]=3)=[N:15][CH:16]=2)[NH:20][C:21]1=[O:34]

Komponenten

4

Edukt 3

HCID 129995062-Methyl-1,2,3,4-tetrahydroisoquinolin-7-amineHCID 178507161HCID 178507161, VerbindungHCID 178507162HCID 178507162, Verbindung

Produkt 1

HCID 178480072HCID 178480072, Verbindung

Versuchsvorschrift

15 mg of the entitled compound was obtained as a white solid according to the same method as in Example 2, for which, however, 2-methyl-1,2,3,4-tetrahydroisoquinolin-7-amine was used in place of 2,4,4-trimethyl-1,2,3,4-tetrahydroisoquinolin-7-amine in Example 2, and 7-chloro-3-(2,6-dichloro-4-fluorophenyl)-4-imino-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one obtained in Production Example 4 was used in place of 7-chloro-3-(2,6-dichlorophenyl)-4-imino-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one.

Aufarbeitung

  1. customobtained in Production Example 4

Quellen und Nachweise

ORD-Eintrag
ord-60887eb79e9b44d38fc5d8fc0c8994d4
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08436004B2

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