2-Methyl-1,2,3,4-tetrahydroisoquinolin-6-amine → HCID 58289858, Verbindung

HRID 2088757

Reaktionsgleichung

Reaktionsgleichung von HRID 2088757
[CH3:1][N:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([NH2:12])[CH:8]=2)[CH2:3]1.Cl[C:14]1[N:19]=[C:18]2[N:20]([CH3:34])[C:21](=[O:33])[N:22]([C:25]3[C:30]([Cl:31])=[CH:29][CH:28]=[CH:27][C:26]=3[Cl:32])[C:23](=[NH:24])[C:17]2=[CH:16][N:15]=1.ClC1N=C2NC(=O)N(C3C(Cl)=CC=CC=3Cl)C(=N)C2=CN=1>>[Cl:31][C:30]1[CH:29]=[CH:28][CH:27]=[C:26]([Cl:32])[C:25]=1[N:22]1[C:23](=[NH:24])[C:17]2[C:18](=[N:19][C:14]([NH:12][C:7]3[CH:8]=[C:9]4[C:4](=[CH:5][CH:6]=3)[CH2:3][N:2]([CH3:1])[CH2:11][CH2:10]4)=[N:15][CH:16]=2)[N:20]([CH3:34])[C:21]1=[O:33]

Komponenten

4

Edukt 3

HCID 214367412-Methyl-1,2,3,4-tetrahydroisoquinolin-6-amineHCID 58289789HCID 58289789, VerbindungHCID 178507161HCID 178507161, Verbindung

Produkt 1

HCID 58289858HCID 58289858, Verbindung

Versuchsvorschrift

28 mg of the entitled compound was obtained as a white solid according to the same method as in Example 2, for which, however, 2-methyl-1,2,3,4-tetrahydroisoquinolin-6-amine was used in place of 2,4,4-trimethyl-1,2,3,4-tetrahydroisoquinolin-7-amine in Example 2, and 7-chloro-3-(2,6-dichlorophenyl)-4-imino-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one obtained in Production Example 7 was used in place of 7-chloro-3-(2,6-dichlorophenyl)-4-imino-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one.

Aufarbeitung

  1. customobtained in Production Example 7

Quellen und Nachweise

ORD-Eintrag
ord-92a2fd501061445d9b378be8e437cfde
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08436004B2

Verknüpfte Notizen

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