Sodium Carbonate → 3-(2,6-dichloropyridin-4-yl)-5-methoxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

https://huagongshe.com/de/reaction/2089017

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Sodium Carbonate	HCID 10340	—
Edukt	2,6-Dichloro-4-iodopyridine	HCID 11737393	—
Edukt	5-Methoxy-1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine	HCID 66889277	—
Katalysator	HCID 178418476	HCID 178418476	—
Lösungsmittel	Water	HCID 962	—
Lösungsmittel	Dimethoxyethane ethanol water	HCID 86587095	—
Produkt	3-(2,6-dichloropyridin-4-yl)-5-methoxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine	HCID 87192554	56%

Reaktionsbedingungen

Temperatur	80 °C

Reaktionsschritte

A suspension of Example 149c (0.150 g, 0.362 mmol), 2,6-dichloro-4-iodopyridine (0.099 g, 0.362 mmol), dichlorobis(triphenylphosphine)palladium(II) (10.17 mg, 0.014 mmol) and 1M sodium carbonate (0.290 mL, 0.290 mmol) in dimethoxyethane/EtOH/water (7:2:3, 2.5 mL) was degassed and heated at 80° C. overnight. After cooling, the suspension was diluted with water and extracted with EtOAc (2×). The suspension in the aq. layer was filtered, washed with water, and dried to give 88.0 mg of the title compound

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08435980B2
Quelldatensatz	uspto-grants-2013_05
ORD ID	ord-18cb2881cc434b15bb93ad7040602c4b
Quellennotiz	uspto-grants-2013_05