HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Trifluoroacetic acid → N-Azetidin-3-yl-2-(5-trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetamide TFA salt
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Trifluoroacetic acid | HCID 6422 | — |
| Edukt | 3-[2-(5-Trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetylamino]-azetidine-1-carboxylic acid tert-butyl ester | HCID 67478904 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | N-Azetidin-3-yl-2-(5-trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetamide TFA salt | HCID 86660176 | — |
Reaktionsschritte
3-[2-(5-Trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetylamino]-azetidine-1-carboxylic acid tert-butyl ester (500 mg, 1.21 mmol) in DCM (5 mL) and TFA (5 mL) was stirred at room temperature for 1 hour. The solvent was removed and then lyophilized overnight to give the title compound as colorless oil.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08436023B2 |
| Quelldatensatz | uspto-grants-2013_05 |
| ORD ID | ord-da8966db0cee432a98f071861064bc60 |
| Quellennotiz | uspto-grants-2013_05 |