Hydrochloric Acid → HCID 54756036, Verbindung

HRID 2089140

Reaktionsgleichung

Reaktionsgleichung von HRID 2089140
C([Si](C)(C)[O:6][CH:7]1[CH2:12][CH2:11][CH:10]([N:13]2[CH2:16][CH:15]([NH:17][C:18](=[O:34])[CH2:19][NH:20][C:21]3[C:25]4[CH:26]=[C:27]([C:30]([F:33])([F:32])[F:31])[CH:28]=[CH:29][C:24]=4[O:23][N:22]=3)[CH2:14]2)[CH2:9][CH2:8]1)(C)(C)C.Cl>C1COCC1>[OH:6][CH:7]1[CH2:8][CH2:9][CH:10]([N:13]2[CH2:14][CH:15]([NH:17][C:18](=[O:34])[CH2:19][NH:20][C:21]3[C:25]4[CH:26]=[C:27]([C:30]([F:32])([F:33])[F:31])[CH:28]=[CH:29][C:24]=4[O:23][N:22]=3)[CH2:16]2)[CH2:11][CH2:12]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 58548829N-{1-[4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexyl]-azetidin-3-yl}-2-(5-trifluoromethyl-benzo[d]isoxazol-3-ylamino)-acetamide

Produkt 1

HCID 54756036HCID 54756036, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of N-{1-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-azetidin-3-yl}-2-(5-trifluoro-methyl-benzo[d]isoxazol-3-ylamino)-acetamide (as prepared in Example 8, 20 mg, 0.033 mmol) in THF (2 mL) was added 1 N HCl (200 L) and stirred at RT for 1.5 hours. The reaction was quenched with 1 N NaOH to pH=10 and then extracted with EtOAc and dried over anhydrous Na2SO4, filtered and concentrated to give the title product.

Aufarbeitung

  1. customThe reaction was quenched with 1 N NaOH to pH=10
  2. extractionextracted with EtOAc
  3. dry with materialdried over anhydrous Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-ad330455d3cc40d7ba979a7c7c94dc20
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08436023B2

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