Glyoxylic Acid → (1-Methyl-5-trifluoromethyl-1H-indazol-3-ylamino)-acetic acid
Reaktionsgleichung
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([F:14])([F:13])[F:12])=[CH:8][CH:9]=2)[C:4]([NH2:15])=[N:3]1.[C:16]([OH:20])(=[O:19])[CH:17]=O>>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([F:12])([F:13])[F:14])=[CH:8][CH:9]=2)[C:4]([NH:15][CH2:17][C:16]([OH:20])=[O:19])=[N:3]1Komponenten
3
Versuchsvorschrift
The title compound was prepared as white solid from reductive amination of 1-methyl-5-trifluoromethyl-1H-indazol-3-ylamine (as prepared in the previous step) and glyoxylic acid using the procedure described in Step B of Example 1.
Quellen und Nachweise
- ORD-Eintrag
- ord-8293e9c914924dd5a2f77887b30b5deb
- Quelldatensatz
- uspto-grants-2013_05
- Patentnummer
- US08436023B2
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