Allyl bromide → 2-(1-Allyl-5-trifluoromethyl-1H-indazol-3-yl)-isoindole-1,3-dione

HRID 2089230Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2089230
[F:1][C:2]([F:24])([F:23])[C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[N:12]1[C:20](=[O:21])[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]1=[O:22].C([O-])([O-])=O.[K+].[K+].[CH2:31](Br)[CH:32]=[CH2:33]>CC(C)=O>[CH2:33]([N:8]1[C:9]2[C:5](=[CH:4][C:3]([C:2]([F:23])([F:1])[F:24])=[CH:11][CH:10]=2)[C:6]([N:12]2[C:20](=[O:21])[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]2=[O:22])=[N:7]1)[CH:32]=[CH2:31]

Komponenten

5

Edukt 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 585488622-(5-Trifluoromethyl-1H-indazol-3-yl)-isoindole-1,3-dione

Produkt 1

HCID 585488592-(1-Allyl-5-trifluoromethyl-1H-indazol-3-yl)-isoindole-1,3-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

2-(5-Trifluoromethyl-1H-indazol-3-yl)-isoindole-1,3-dione (500 mg, 1.51 mmol), K2CO3 (313 mg, 2.26 mmol) and allyl bromide (365 mg, 3.02 mmol) in acetone (10 mL) were heated to reflux overnight. The reaction was filtered, and the residue was concentrated and purified by silica gel column chromatography using hexanes:ethyl acetate 2:1 to give the title compound as white solid.

Aufarbeitung

  1. temperatureto reflux overnight
  2. filtrationThe reaction was filtered
  3. concentrationthe residue was concentrated
  4. custompurified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-bb13fa88d3624b88a62ae5e32cab2fb9
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08436023B2

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