Triethylamine → Tert-butyl(2-fluoro-5-methoxyphenoxy)dimethylsilane

HRID 2089676Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2089676
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[OH:10].C(N(CC)CC)C.[Si:18](Cl)([C:21]([CH3:24])([CH3:23])[CH3:22])([CH3:20])[CH3:19].[OH-].[Na+]>O1CCCC1.CCCCCCC>[C:21]([Si:18]([O:10][C:3]1[CH:4]=[C:5]([O:8][CH3:9])[CH:6]=[CH:7][C:2]=1[F:1])([CH3:20])[CH3:19])([CH3:24])([CH3:23])[CH3:22]

Komponenten

7

Edukt 4

HCID 8471TriethylamineHCID 14798Sodium HydroxideHCID 28928tert-Butyldimethylsilyl chlorideHCID 141189572-Fluoro-5-methoxyphenol

Produkt 1

HCID 67469961Tert-butyl(2-fluoro-5-methoxyphenoxy)dimethylsilaneAusbeute 94,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028TetrahydrofuranLösungsmittel2×HCID 8900HeptaneLösungsmittel

Versuchsvorschrift

To a flask, 2-fluoro-5-methoxyphenol (6.00 g, 42 mmol), triethylamine (5.77 g, 57 mmol), and tetrahydrofuran (36.0 mL) were added, and the resulting mixture was cooled in an ice water bath under nitrogen atmosphere. To the solution, a solution of tert-butyldimethylsilyl chloride (6.89 g, 44 mmol) in tetrahydrofuran (30.0 mL) was added dropwise, and the resulting mixture was stirred overnight at room temperature. To the reaction mixture, heptane and a 2 N aqueous sodium hydroxide solution were added, and the resulting mixture was extracted. The organic layer was washed with water, and concentrated under reduced pressure to obtain the captioned compound (10.2 g) as a light brownish-red oil.

Aufarbeitung

  1. temperaturethe resulting mixture was cooled in an ice water bath under nitrogen atmosphere
  2. extractionthe resulting mixture was extracted
  3. washThe organic layer was washed with water
  4. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-33c135b237134441b736a2e66c26860e
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08436009B2

Notizen zur Reaktion

Wird geladen…