Dimethylamine → HCID 25106689, Verbindung

HRID 2090246Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2090246
[NH2:1][C:2]1[C:11]2[N:12]=[C:13]([CH2:35][O:36][CH2:37][CH3:38])[N:14]([CH2:15][CH2:16][CH2:17][N:18]([CH2:23][C:24]3[CH:25]=[C:26]([CH2:30][C:31]([O:33][CH3:34])=[O:32])[CH:27]=[CH:28][CH:29]=3)[C:19](=[O:22])[CH2:20]Cl)[C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.[CH3:39][NH:40][CH3:41]>CN(C=O)C>[CH3:34][O:33][C:31](=[O:32])[CH2:30][C:26]1[CH:27]=[CH:28][CH:29]=[C:24]([CH2:23][N:18]([CH2:17][CH2:16][CH2:15][N:14]2[C:10]3[C:9]4[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=4[N:3]=[C:2]([NH2:1])[C:11]=3[N:12]=[C:13]2[CH2:35][O:36][CH2:37][CH3:38])[C:19](=[O:22])[CH2:20][N:40]([CH3:41])[CH3:39])[CH:25]=1

Komponenten

4

Edukt 2

HCID 674DimethylamineHCID 68432292HCID 68432292, Verbindung

Produkt 1

HCID 25106689HCID 25106689, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

The product from step (vi) (30 mg) was dissolved in DMF (2 mL) then a solution of dimethylamine (2M in THF, 0.279 mL) was added at rt under nitrogen. The resulting solution was stirred at rt for 16 h. The mixture was purified by RPHPLC to give the title compound, yield 4.5 mg.

Aufarbeitung

  1. customThe mixture was purified by RPHPLC

Quellen und Nachweise

ORD-Eintrag
ord-fce58ec914cd4d119d2ac232c5bdee8a
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08436178B2

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