2-(4-Methylpiperazin-1-yl)pyridine-4-boronic acid, pinacol ester → 4-(4-Methylpiperazin-1-yl)-6-[7-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-3,4-dihydroisoquinolin-2(1H)-yl]pyrimidin-2-amine

HRID 2090284

Reaktionsgleichung

Reaktionsgleichung von HRID 2090284
Br[C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][N:8]([C:12]3[CH:17]=[C:16]([N:18]4[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]4)[N:15]=[C:14]([NH2:25])[N:13]=3)[CH2:9]2)=[CH:4][CH:3]=1.[CH3:26][N:27]1[CH2:32][CH2:31][N:30]([C:33]2[CH:38]=[C:37](B3OC(C)(C)C(C)(C)O3)[CH:36]=[CH:35][N:34]=2)[CH2:29][CH2:28]1>>[CH3:24][N:21]1[CH2:22][CH2:23][N:18]([C:16]2[CH:17]=[C:12]([N:8]3[CH2:7][CH2:6][C:5]4[C:10](=[CH:11][C:2]([C:37]5[CH:36]=[CH:35][N:34]=[C:33]([N:30]6[CH2:29][CH2:28][N:27]([CH3:26])[CH2:32][CH2:31]6)[CH:38]=5)=[CH:3][CH:4]=4)[CH2:9]3)[N:13]=[C:14]([NH2:25])[N:15]=2)[CH2:19][CH2:20]1

Komponenten

3

Edukt 2

HCID 27695372-(4-Methylpiperazin-1-yl)pyridine-4-boronic acid, pinacol esterHCID 467010484-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine

Produkt 1

HCID 594023024-(4-Methylpiperazin-1-yl)-6-[7-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-3,4-dihydroisoquinolin-2(1H)-yl]pyrimidin-2-amine

Versuchsvorschrift

This compound was prepared by using procedures analogous to those described for the synthesis of Example 2 starting from 4-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine and 1-methyl-4-[4(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine (Oadwood, Cat. No. 021854). LCMS (M+H)+: m/z=500.5.

Aufarbeitung

  1. customThis compound was prepared

Quellen und Nachweise

ORD-Eintrag
ord-f77c56a60ce244b8a6de209918a5af26
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08436008B2

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