Hydrochloric Acid → 2-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid

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The mixture of 2-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1,2,3,4-tetrahydroisoquinoline-7-carbonitrile (1 g, 2.86 mmol) and sodium hydroxide (801 mg, 20.0 mmol) in water (30 ml) was heated at 100° C. for 2 days. The reaction mixture was cooled to r.t., and acidified carefully to neutral with 6N HCl aqueous solution. The precipitate was filtered and washed with a little water, dried under vacuum to afford the desired compound (1 g, 94.8%). LCMS(M+H)+: m/z=369.1.

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