Hydrochloric Acid → Isobutyric acid (1s,2s)-6-fluoro-2-[2-({3-[(2-fluoro-ethyl)-(3-methoxy-2-methoxymethyl-2-methyl-propyl)-amino]-propyl}-methyl-amino)-ethyl]-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester dihydrochloride salt

HRID 2090574Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2090574
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C@H:8]([CH:12]([CH3:14])[CH3:13])[C@@:7]([O:35][C:36](=[O:40])[CH:37]([CH3:39])[CH3:38])([CH2:15][CH2:16][N:17]([CH2:19][CH2:20][CH2:21][N:22]([CH2:32][CH2:33][F:34])[CH2:23][C:24]([CH2:29][O:30][CH3:31])([CH3:28])[CH2:25][O:26][CH3:27])[CH3:18])[CH2:6][CH2:5]2.[ClH:41]>CCOC(C)=O>[ClH:41].[ClH:41].[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C@H:8]([CH:12]([CH3:14])[CH3:13])[C@@:7]([O:35][C:36](=[O:40])[CH:37]([CH3:39])[CH3:38])([CH2:15][CH2:16][N:17]([CH2:19][CH2:20][CH2:21][N:22]([CH2:32][CH2:33][F:34])[CH2:23][C:24]([CH2:29][O:30][CH3:31])([CH3:28])[CH2:25][O:26][CH3:27])[CH3:18])[CH2:6][CH2:5]2

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 45381136isobutyric acid (1S,2S)-6-fluoro-2-[2-({3-[(2-fluoro-ethyl)-(3-methoxy-2-methoxymethyl-2-methyl-propyl)-amino]-propyl}-methyl-amino)-ethyl]-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester

Produkt 1

HCID 86657122Isobutyric acid (1s,2s)-6-fluoro-2-[2-({3-[(2-fluoro-ethyl)-(3-methoxy-2-methoxymethyl-2-methyl-propyl)-amino]-propyl}-methyl-amino)-ethyl]-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester dihydrochloride salt

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

411 mg of isobutyric acid (1S,2S)-6-fluoro-2-[2-({3-[(2-fluoro-ethyl)-(3-methoxy-2-methoxymethyl-2-methyl-propyl)-amino]-propyl}-methyl-amino)-ethyl]-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester were dissolved in 10 mL EtOAc, the solution was cooled with an ice bath and 2.4 mL of 3M HCl in EtOAC were added. The reaction mixture was evaporated to dryness without heating to give the desired isobutyric acid (1S,2S)-6-fluoro-2-[2-({3-[(2-fluoro-ethyl)-(3-methoxy-2-methoxymethyl-2-methyl-propyl)-amino]-propyl}-methyl-amino)-ethyl]-1-isopropyl-1,2,3,4-tetrahydro-naphthalen-2-yl ester dihydrochloride salt.

Aufarbeitung

  1. temperaturethe solution was cooled with an ice bath
  2. customThe reaction mixture was evaporated to dryness
  3. temperaturewithout heating

Quellen und Nachweise

ORD-Eintrag
ord-8d691f5156da42f4949101d52fe5495e
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08436205B2

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