1,4-Dioxane hydrochloride → HCID 66989598, Verbindung

HRID 2091549Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2091549
C(OC([NH:8][CH2:9][C:10]([O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[C:20]([CH2:32][O:33][C:34]3[CH:39]=[C:38]([F:40])[CH:37]=[CH:36][C:35]=3[CH3:41])=[C:21]3[C:26](=[CH:27][CH:28]=2)[NH:25][C:24]([CH3:30])([CH3:29])[CH:23]=[C:22]3[CH3:31])=[C:15]([O:42][CH3:43])[CH:14]=1)=[O:11])=O)(C)(C)C.[ClH:44].O1CCOCC1>O1CCOCC1>[ClH:44].[NH2:8][CH2:9][C:10]([O:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[C:20]([CH2:32][O:33][C:34]3[CH:39]=[C:38]([F:40])[CH:37]=[CH:36][C:35]=3[CH3:41])=[C:21]3[C:26](=[CH:27][CH:28]=2)[NH:25][C:24]([CH3:30])([CH3:29])[CH:23]=[C:22]3[CH3:31])=[C:15]([O:42][CH3:43])[CH:14]=1)=[O:11]

Komponenten

4

Edukt 2

HCID 204431481,4-Dioxane hydrochlorideHCID 24798769HCID 24798769, Verbindung

Produkt 1

HCID 66989598HCID 66989598, VerbindungAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

6-(4-t-Butoxycarbonylaminoacetoxy-2-methoxyphenyl)-5-(5-fluoro-2-methylphenoxymethyl)-2,2,4-trimethyl-1,2-dihydroquinoline (Reference Compound No. 4-1, 20.1 mg, 0.034 mmol) was dissolved in 1,4-dioxane (0.5 mL), 4N hydrogen chloride/1,4-dioxane solution (34 μL) was added thereto, and then the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure to give the titled compound (17.5 mg) as a colorless solid. (Yield 98%)

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-56a0f8b577244de692e6a3137511bb93
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08440660B2

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