Acetyl chloride → HCID 178496609, Verbindung

HRID 2091668Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2091668
C(OC([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([O:15][CH3:16])[CH2:11][CH2:10]1)=O)(C)(C)C.C(Cl)(=O)C>C(O)C>[CH3:16][O:15][C@H:12]1[CH2:13][CH2:14][C@H:9]([NH2:8])[CH2:10][CH2:11]1

Komponenten

4

Edukt 2

HCID 6367Acetyl chlorideHCID 178496620HCID 178496620, Verbindung

Produkt 1

HCID 178496609HCID 178496609, VerbindungAusbeute 126,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

trans-(tert-Butoxy)-N-(4-methoxycyclohexyl)carboxamide (642 mg, 2.80 mmol) was dissolved in ethanol (5 mL) and cooled to 0° C. Acetyl chloride (1.5 mL) was added and the reaction was allowed to reach room temperature and stirred overnight. Solvent was removed in vacuo to give the desired product (458 mg, quantitative yield) as a hydrochloride salt. ES-MS: 130 (M+1).

Aufarbeitung

  1. customto reach room temperature
  2. customSolvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1b0fb6cbc1954dc781059024e98c314a
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08440661B2

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