Sodium Hydroxide → HCID 57770667, Verbindung

HRID 2091823Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2091823
C[O:2][C:3](=[O:26])[C:4]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][N:11]=2)[CH:7]=[C:6]([C:17]2[N:18]([CH2:22][CH:23]3[CH2:25][CH2:24]3)[N:19]=[CH:20][CH:21]=2)[CH:5]=1.[OH-].[Na+]>CO>[CH:23]1([CH2:22][N:18]2[C:17]([C:6]3[CH:5]=[C:4]([CH:9]=[C:8]([C:10]4[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][N:11]=4)[CH:7]=3)[C:3]([OH:26])=[O:2])=[CH:21][CH:20]=[N:19]2)[CH2:25][CH2:24]1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 57770606HCID 57770606, Verbindung

Produkt 1

HCID 57770667HCID 57770667, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

3-(2-Cyclopropylmethyl-2H-pyrazol-3-yl)-5-(5-methyl-pyridin-2-yl)-benzoic acid methyl ester (1.14 g, 3.27 mmol was dissolved in 20 mL MeOH, and 3N aqueous NaOH (3 mL) was added. The reaction mixture was stirred at room temperature for three hours, then concentrated under reduced pressure. The residue was acidified to pH 3 and extracted with EtOAc. The combined organic layers were dried over MgSO4, filtered and concentrated under reduced pressure to give 0.9 g of 3-(2-cyclopropylmethyl-2H-pyrazol-3-yl)-5-(5-methyl-pyridin-2-yl)-benzoic acid, MS (M+H)=334.

Aufarbeitung

  1. concentrationconcentrated under reduced pressure
  2. extractionextracted with EtOAc
  3. dry with materialThe combined organic layers were dried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-4ebe2dfed5a1417cb4d39114c2b83188
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08440673B2

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