4-Bromophenyl isocyanate → 4-[3-(4-Bromo-phenyl)-ureido]-N,N-dimethyl-benzamide

HRID 2092514Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2092514
[NH2:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([N:8]([CH3:10])[CH3:9])=[O:7])=[CH:4][CH:3]=1.[Br:13][C:14]1[CH:19]=[CH:18][C:17]([N:20]=[C:21]=[O:22])=[CH:16][CH:15]=1>C(Cl)Cl>[Br:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:22])[NH:1][C:2]2[CH:12]=[CH:11][C:5]([C:6]([N:8]([CH3:10])[CH3:9])=[O:7])=[CH:4][CH:3]=2)=[CH:16][CH:15]=1

Komponenten

4

Edukt 2

HCID 756094-Bromophenyl isocyanateHCID 2355274-Amino-N,N-dimethylbenzamide

Produkt 1

HCID 689172644-[3-(4-Bromo-phenyl)-ureido]-N,N-dimethyl-benzamideAusbeute 88,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 4-amino-N,N-dimethyl-benzamide (3.5 g, 0.0213 mol), TEA (2.15 g, 0.0213 mol) in DCM (50 mL) was added 4-bromophenyl isocyanate (5.07 g, 0.0256 mol). The reaction mixture was stirred at room temperature for 12 h. The white solid was obtained and was filtered and dried to afford the title compound [6.8 g, 88%]; LC-MS (ESI): Calculated mass: 361.0; Observed mass: 362.0 [M+H]+ (RT: 0.17 min).

Aufarbeitung

  1. customThe white solid was obtained
  2. filtrationwas filtered
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-526d5903a1ba42cfb6e73a84c3b2cb06
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08440662B2

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