2,2,2-Trichloroethyl chloroformate → {5-[7-(3-Methanesulfonyl-phenyl)-4-morpholin-4-yl-quinazolin-2-yl]-pyridine-2-yl}-carbamic acid 2,2,2-trichloroethyl ester

HRID 2092542Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2092542
[CH3:1][S:2]([C:5]1[CH:6]=[C:7]([C:11]2[CH:20]=[C:19]3[C:14]([C:15]([N:28]4[CH2:33][CH2:32][O:31][CH2:30][CH2:29]4)=[N:16][C:17]([C:21]4[CH:22]=[CH:23][C:24]([NH2:27])=[N:25][CH:26]=4)=[N:18]3)=[CH:13][CH:12]=2)[CH:8]=[CH:9][CH:10]=1)(=[O:4])=[O:3].[Cl:34][C:35]([Cl:42])([Cl:41])[CH2:36][O:37][C:38](Cl)=[O:39]>C(Cl)Cl>[Cl:34][C:35]([Cl:42])([Cl:41])[CH2:36][O:37][C:38](=[O:39])[NH:27][C:24]1[CH:23]=[CH:22][C:21]([C:17]2[N:16]=[C:15]([N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)[C:14]3[C:19](=[CH:20][C:11]([C:7]4[CH:8]=[CH:9][CH:10]=[C:5]([S:2]([CH3:1])(=[O:3])=[O:4])[CH:6]=4)=[CH:12][CH:13]=3)[N:18]=2)=[CH:26][N:25]=1

Komponenten

4

Edukt 2

HCID 870632,2,2-Trichloroethyl chloroformateHCID 675144285-[7-(3-Methanesulfonyl-phenyl)-4-morpholin-4-yl-quinazolin-2-yl]-pyridin-2-ylamine

Produkt 1

HCID 67514937{5-[7-(3-Methanesulfonyl-phenyl)-4-morpholin-4-yl-quinazolin-2-yl]-pyridine-2-yl}-carbamic acid 2,2,2-trichloroethyl esterAusbeute 57.934,398 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a cooled solution (0° C.) of 5-[7-(3-methanesulfonyl-phenyl)-4-morpholin-4-yl-quinazolin-2-yl]-pyridin-2-ylamine (125 mg, 0.000271 mmol) in DCM (4 mL) was added 2,2,2-trichloroethylchloroformate (0.054 mL, 0.0004 mol) and TEA (0.056 mL, 0.0004 mol). The reaction mixture was allowed to stir at ambient temperature for 5 h. The volatiles were evaporated to get the crude product (100 mg). This material was taken to the next step without further purification.

Aufarbeitung

  1. customThe volatiles were evaporated

Quellen und Nachweise

ORD-Eintrag
ord-4f9db08980334e399c724fbe173f76ad
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08440662B2

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