4-Ethylphenethylamine → 2-[2-(4-Ethyl-phenyl)-ethyl]-8-hydroxy-2-aza-spiro[4.5]decan-1-one
Reaktionsgleichung
C(O[C:4]([C:6]1([CH2:13][CH2:14]OC)[CH2:11][CH2:10][CH:9]([OH:12])[CH2:8][CH2:7]1)=[O:5])C.[CH2:17]([C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][NH2:27])=[CH:21][CH:20]=1)[CH3:18]>>[CH2:17]([C:19]1[CH:24]=[CH:23][C:22]([CH2:25][CH2:26][N:27]2[CH2:14][CH2:13][C:6]3([CH2:7][CH2:8][CH:9]([OH:12])[CH2:10][CH2:11]3)[C:4]2=[O:5])=[CH:21][CH:20]=1)[CH3:18]Komponenten
3
Versuchsvorschrift
The title compound was prepared in analogy to example 1, step 4 from 4-hydroxy-1-(2-methoxy-ethyl)-cyclohexanecarboxylic acid ethyl ester (obtained in example 2, step 3) by treatment with 2-(4-ethylphenyl)-ethylamine [CAS Reg. No. 64353-29-3]. MS (m/e): 302.3 [MH+].
Quellen und Nachweise
- ORD-Eintrag
- ord-dc6511f38bb143fe894678b4f730d6b3
- Quelldatensatz
- uspto-grants-2013_05