Hydrochloric Acid → 2-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-2-aza-spiro[4.5]decane-1,8-dione

HRID 2092706

Reaktionsgleichung

Reaktionsgleichung von HRID 2092706
[F:1][C:2]1([F:26])[O:6][C:5]2[CH:7]=[CH:8][C:9]([N:11]3[CH2:24][CH2:23][C:13]4([CH2:22][CH2:21][C:16]5(OCC[O:17]5)[CH2:15][CH2:14]4)[C:12]3=[O:25])=[CH:10][C:4]=2[O:3]1.Cl>>[F:26][C:2]1([F:1])[O:6][C:5]2[CH:7]=[CH:8][C:9]([N:11]3[CH2:24][CH2:23][C:13]4([CH2:14][CH2:15][C:16](=[O:17])[CH2:21][CH2:22]4)[C:12]3=[O:25])=[CH:10][C:4]=2[O:3]1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 6658042110-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one

Produkt 1

HCID 665800062-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-2-aza-spiro[4.5]decane-1,8-dione

Versuchsvorschrift

The title compound was prepared in analogy to example 133 step 5 from 10-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one (described in example 336, step 1) by treatment with 2M HCl. White solid. MS (m/e): 324.2 [MH+].

Quellen und Nachweise

ORD-Eintrag
ord-795152912e6d42de8e2c5b2ce3b45ea3
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08440710B2

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