Nitric Acid → N-[4-(dimethylamino)-2-nitrophenyl]acetamide

HRID 2093041

Reaktionsgleichung

Reaktionsgleichung von HRID 2093041
[CH3:1][N:2]([CH3:13])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:12])[CH3:11])=[CH:5][CH:4]=1.[N+:14]([O-])([OH:16])=[O:15].OS(O)(=O)=O>>[CH3:13][N:2]([CH3:1])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:12])[CH3:11])=[C:5]([N+:14]([O-:16])=[O:15])[CH:4]=1

Komponenten

4

Edukt 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 819684'-Dimethylaminoacetanilide

Produkt 1

HCID 4396139N-[4-(dimethylamino)-2-nitrophenyl]acetamide

Versuchsvorschrift

N-[4-(dimethylamino)phenyl]acetamide obtained in step I above was nitrated using nitric acid (1.2 eq)+H2SO4 (1.0 eq) at 0 to 5° C. for 2 hrs. After the completion of the reaction, reaction mixture was added to ice and pH was adjusted to 8, extracted with dichloromethane, which was evaporated to dryness to obtain N-[4-(dimethylamino)-2-nitrophenyl]acetamide.

Aufarbeitung

  1. customat 0 to 5° C.
  2. customfor 2 hrs
  3. customAfter the completion of the reaction, reaction mixture
  4. additionwas added to ice and pH
  5. extractionextracted with dichloromethane, which
  6. customwas evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-d2a14774e774469797592a2ed1dfd384
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08440830B2

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