HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Thionyl Chloride → 4-(Morpholin-3-on-4-yl)-3-nitro-benzoic acid chloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Thionyl Chloride | HCID 24386 | — |
| Edukt | 4-(2-Carboxymethoxy-ethylamino)-3-nitro-benzoic acid | HCID 66731908 | — |
| Katalysator | Dimethylformamide | HCID 6228 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | 4-(Morpholin-3-on-4-yl)-3-nitro-benzoic acid chloride | HCID 86069407 | — |
Reaktionsschritte
290 mg (1.02 mmol) 4-(2-carboxymethoxy-ethylamino)-3-nitro-benzoic acid in 100 ml dichloromethane are combined with 0.186 ml (2.55 mmol) thionyl chloride and 2 drops of DMF and refluxed for one day. After evaporation of the solution i. vac. it is evaporated with toluene and the residue is further reacted without any more purification.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08445525B2 |
| Quelldatensatz | uspto-grants-2013_05 |
| ORD ID | ord-cc7afd95aa38442e8bcc227179813f27 |
| Quellennotiz | uspto-grants-2013_05 |