Ethyl trichloroacetate → N-methyl-4-(4-(2,2,2-trichloroacetamido)phenoxy)picolinamide

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

4-(4-aminophenoxy)-N-methylpicolinamide (35 g, 0.144 mol) was mixed with ethyl-2,2,2-trichloroacetate (50 ml, 0.27 mol) in toluene (350 ml) at ambient temperature. The mixture was then heated to 100° C. under distillation mode for 2-3 hours. The organic solvent was degassed under reduced pressure to obtain oil. This oil was triturated with hexane (500 ml) to obtain (49 g) of the desired solid.

Herkunft & Nachweise