Methyl iodide → (S)-4-[(S)-4-((S)-4-Hydroxy-6-aza-spiro[2.5]oct-6-yl)-1-hydroxymethyl-4-oxo-butyl]-2-methyl-3-oxo-piperazine-1-carboxylic acid (3-chloro-4-trifluoromethoxy-phenyl)-methyl-amide

Reaktionsgleichung

I[CH3:2].[Cl:3][C:4]1[CH:5]=[C:6]([NH:15][C:16]([N:18]2[CH2:23][CH2:22][N:21]([C@H:24]([CH2:38][OH:39])[CH2:25][CH2:26][C:27]([N:29]3[CH2:36][CH2:35][C:32]4([CH2:34][CH2:33]4)[C@H:31]([OH:37])[CH2:30]3)=[O:28])[C:20](=[O:40])[C@@H:19]2[CH3:41])=[O:17])[CH:7]=[CH:8][C:9]=1[O:10][C:11]([F:14])([F:13])[F:12]>C(#N)C.[Ag-]=O>[Cl:3][C:4]1[CH:5]=[C:6]([N:15]([CH3:2])[C:16]([N:18]2[CH2:23][CH2:22][N:21]([C@H:24]([CH2:38][OH:39])[CH2:25][CH2:26][C:27]([N:29]3[CH2:36][CH2:35][C:32]4([CH2:33][CH2:34]4)[C@H:31]([OH:37])[CH2:30]3)=[O:28])[C:20](=[O:40])[C@@H:19]2[CH3:41])=[O:17])[CH:7]=[CH:8][C:9]=1[O:10][C:11]([F:13])([F:14])[F:12]