(R)-2-(3,4-Dichloro-phenylamino)-propionic acid → HCID 67074412, Verbindung

HRID 2095590

Reaktionsgleichung

Reaktionsgleichung von HRID 2095590
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C@H:10]([CH3:14])C(O)=O)[CH:5]=[CH:6][C:7]=1Cl.BrC1C=CC([C:22]([F:25])([F:24])[F:23])=C(Cl)C=1.BrCC[C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31]>>[C:33]([O:32][C:30](=[O:31])[CH2:14][CH2:10][NH:9][C:4]1[CH:5]=[CH:6][C:7]([C:22]([F:23])([F:24])[F:25])=[C:2]([Cl:1])[CH:3]=1)([CH3:36])([CH3:35])[CH3:34]

Komponenten

4

Edukt 3

HCID 182146(R)-2-(3,4-Dichloro-phenylamino)-propionic acidHCID 256128tert-Butyl 3-bromopropionateHCID 202698484-Bromo-2-chlorobenzotrifluoride

Produkt 1

HCID 67074412HCID 67074412, VerbindungAusbeute 53 %

Versuchsvorschrift

In analogy to the procedure described for intermediate 31, 4-bromo-2-chloro-1-trifluoromethyl-benzene and tert-butyl 3-bromopropionate gave the title compound in 53% yield as yellow oil. MS: 323 (M+, Cl).

Quellen und Nachweise

ORD-Eintrag
ord-03b14744d21f4c648d78db792fac9c37
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08445674B2

Verknüpfte Notizen

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