Sodium Hydroxide → 6-Phenylpyridine-2-carboxylic acid N-oxide

HRID 2095780Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2095780
[C:1]1([C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([C:14]([O:16]C)=[O:15])[N+:12]=2[O-:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>CO>[C:1]1([C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([C:14]([OH:16])=[O:15])[N+:12]=2[O-:13])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 66968602Methyl 6-phenylpyridine-2-carboxylate 1-oxide

Produkt 1

HCID 210815386-Phenylpyridine-2-carboxylic acid N-oxideAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of methyl 6-phenylpyridine-2-carboxylate 1-oxide in methanol (2 mL) was added 1N aqueous sodium hydroxide solution (1 mL), and the mixture was stirred at room temperature for 3 hr. The reaction mixture was concentrated, 1N hydrochloric acid was added, the precipitate was collected by filtration, and washed with water to give the title compound (120 mg, 90%) as white crystals.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. addition1N hydrochloric acid was added
  3. filtrationthe precipitate was collected by filtration
  4. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-80304fdec39d401aa6831fee02b3cd34
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08445509B2

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