Sulfuric Acid → 2-Fluoro-3-iodobenzoic acid
Reaktionsgleichung
[F:1][C:2]1[C:9]([I:10])=[CH:8][CH:7]=[CH:6]C=1C#N.S(=O)(=O)(O)[OH:12].[O:16]1[CH2:21][CH2:20]OCC1>>[F:1][C:2]1[C:9]([I:10])=[CH:8][CH:7]=[CH:6][C:20]=1[C:21]([OH:16])=[O:12]Komponenten
4
Reaktionsbedingungen
- Temperatur
- 115 °C
Versuchsvorschrift
A mixture of 2-fluoro-3-iodobenzonitrile (preparation 22a, 5.00 g, 20.2 mmol), dioxane (16 mL) and sulphuric acid (25 mL) was heated to 115° C. After 4 hours, the mixture was cooled and filtered. Water was added to the filtrate and the mixture was extracted with ethyl acetate. The organic layer was dried (MgSO4) and evaporated to give the title compound (4.42 g, 82%) as a solid.
Aufarbeitung
- temperaturethe mixture was cooled
- filtrationfiltered
- additionWater was added to the filtrate
- extractionthe mixture was extracted with ethyl acetate
- dry with materialThe organic layer was dried (MgSO4)
- customevaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-aa40a567225948ffbedee37bd3881c95
- Quelldatensatz
- uspto-grants-2013_05
- Patentnummer
- US08450341B2
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