HCID 59558740, Verbindung → 3-{5-[3-(2-Methoxy-ethoxy)-phenyl]-pyridin-2-oxy}-azetidine-1-carboxylic acid pyridazin-3-ylamide

HRID 2097581

Reaktionsgleichung

Reaktionsgleichung von HRID 2097581
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][C:8]([N:10]2[CH2:13][CH:12]([O:14][C:15]3[CH:20]=[CH:19][C:18](I)=[CH:17][N:16]=3)[CH2:11]2)=[O:9])[N:2]=1.[CH3:22][O:23][CH2:24][CH2:25][O:26][C:27]1[CH:28]=[C:29](B2OC(C)(C)C(C)(C)O2)[CH:30]=[CH:31][CH:32]=1>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][C:8]([N:10]2[CH2:13][CH:12]([O:14][C:15]3[CH:20]=[CH:19][C:18]([C:29]4[CH:30]=[CH:31][CH:32]=[C:27]([O:26][CH2:25][CH2:24][O:23][CH3:22])[CH:28]=4)=[CH:17][N:16]=3)[CH2:11]2)=[O:9])[N:2]=1

Komponenten

3

Edukt 2

HCID 59558740HCID 59558740, VerbindungHCID 66710496US10918640, Example 14

Produkt 1

HCID 442188973-{5-[3-(2-Methoxy-ethoxy)-phenyl]-pyridin-2-oxy}-azetidine-1-carboxylic acid pyridazin-3-ylamideAusbeute 25 %

Versuchsvorschrift

This compound was prepared in similar fashion to the method outlined for Example 5 step 6. Thus 3-(5-iodo-pyridin-2-yloxy)-azetidine-1-carboxylic acid pyridazin-3-ylamide (456 mg, 1.15 mmol) was reacted with 2-[3-(2-Methoxy-ethoxy)-phenyl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (example 5 step 5, 392 mg, 1.50 mmol) to afford title compound (120 mg, 25%) as a colourless powder.

Aufarbeitung

  1. customThis compound was prepared in similar fashion to the method

Quellen und Nachweise

ORD-Eintrag
ord-cf0f1290b8144ddc981081997d41bdef
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08450346B2

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