N-bromobutanimide → 5-Fluoro-2-iodo-4-trifluoromethyl-phenylamine

HRID 2098106Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2098106
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[C:9]([F:12])([F:11])[F:10])[NH2:5].C1C(=O)N([Br:20])C(=O)C1>C(Cl)Cl>[Br:20][C:6]1[CH:7]=[C:8]([C:9]([F:10])([F:11])[F:12])[C:2]([F:1])=[CH:3][C:4]=1[NH2:5]

Komponenten

4

Edukt 2

HCID 67184N-bromobutanimideHCID 27359144-Amino-2-fluorobenzotrifluoride

Produkt 1

HCID 687591875-Fluoro-2-iodo-4-trifluoromethyl-phenylamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To a stirring mixture of 3-fluoro-4-(trifluoromethyl)aniline (1.5 g) in DCM (12 mL) at room temperature was added dropwise a solution of NBS (1.5 g) in DCM (24 mL) over 15 min. The reaction mixture was stirred at rt for 1.5 h. The product mixture was concentrated under reduced pressure to one half of its original volumn. The white solid was filtered off and the crude product mixture was further purified via column chromatography. Retention time (min)=2.490, method [1], MS (ESI) 257.9 (M+H).

Aufarbeitung

  1. concentrationThe product mixture was concentrated under reduced pressure to one half of its original volumn
  2. filtrationThe white solid was filtered off
  3. customthe crude product mixture was further purified via column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-3abb1aa54f554404833c0b7198a05abd
Quelldatensatz
uspto-grants-2013_05
Patentnummer
US08450363B2

Notizen zur Reaktion

Wird geladen…