1-Methylpiperazine → 1-Formyl-4-methylpiperazine
Reaktionsgleichung
ClC1N=C(N2CCOCC2)C2SC(C3C=C(C=CC=3)[C:14](O)=[O:15])=CC=2N=1.[CH3:26][N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[CH3:26][N:27]1[CH2:32][CH2:31][N:30]([CH:14]=[O:15])[CH2:29][CH2:28]1Komponenten
3
Versuchsvorschrift
3-(2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)benzoic acid (60 mg) was reacted with 1-methylpiperizine via General Procedure B to yield 3-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone. Crude 3-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone (71 mg) was coupled to 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole 7 via General Procedure A to yield 22.4 mg of 339. MS (Q1) 540.1 (M)+
Quellen und Nachweise
- ORD-Eintrag
- ord-3894a57667a94e05a155cd80c402a1f6
- Quelldatensatz
- uspto-grants-2013_05
- Patentnummer
- US08450315B2
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