N-bromobutanimide → 4-amino-7-bromo-2,3-dihydro-1H-isoindole-1,3-dione

HRID 20993

Reaktionsgleichung

Reaktionsgleichung von HRID 20993
[NH2:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:4]2[C:5]([NH:7][C:8](=[O:9])[C:3]=12)=[O:6].[Br:13]N1C(=O)CCC1=O>CO>[NH2:1][C:2]1[CH:12]=[CH:11][C:10]([Br:13])=[C:4]2[C:5]([NH:7][C:8](=[O:9])[C:3]=12)=[O:6]

Komponenten

4

Edukt 2

HCID 67184N-bromobutanimideHCID 729141H-Isoindole-1,3(2H)-dione, 4-amino-

Produkt 1

HCID 684890894-amino-7-bromo-2,3-dihydro-1H-isoindole-1,3-dioneAusbeute 74,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

3-Aminophthalimide (2.00 g, 12.3 mmol) was dissolved in methanol (200 mL), and the solution was added with N-bromosuccinimide (2.19 g, 12.3 mmol), followed by stirring at room temperature for 50 minutes. The obtained solid was collected by filtration and washed with methanol to obtain 3-amino-6-bromophthalimide (2.21 g, yield 74%).

Aufarbeitung

  1. filtrationThe obtained solid was collected by filtration
  2. washwashed with methanol

Quellen und Nachweise

ORD-Eintrag
ord-71a5479c3a334ee98e9d5b229fda0e3e
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07745641B2

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